Insulin Stimulates GLUT4 Trafficking to the Syncytiotrophoblast Basal Plasma Membrane in the Human Placenta
نویسندگان
چکیده
منابع مشابه
Na(+)-K(+)-ATPase is distributed to microvillous and basal membrane of the syncytiotrophoblast in human placenta.
Despite its importance for placental function, syncytiotrophoblast Na(+)-K(+)-ATPase has not been studied in detail. We purified syncytiotrophoblast microvillous (MVM) and basal (BM) membranes from full-term human placenta. Western blotting with isoform-specific antibodies demonstrated the presence of the alpha(1)-subunit, but not the alpha(2)- or alpha(3)-subunits, in MVM and BM. Relative dens...
متن کاملDivergent signalling mechanisms involved in insulin-stimulated GLUT4 vesicle trafficking to the plasma membrane.
4 Downes, C. P. (ed.) ( I 998) Special Lipid Signalling Issue Biochim. Biophys. Acta 1436, 1-264 5 De Camilli, P.. Emr, S. D., McPhenon, P. S. and Novick, P. ( 1996) Science 27 I, 1533I539 6 Lemmon. M. A., Falasca, M., Ferguson. K. M. and Schlessinger, J. ( 1997) Trends Cell Biol. 7, 237-242 7 Bottomley. M. 1.. Salim. K. and Panayatou, G. ( I 998) Biochim. Biophys. Acta 1436, 165I 83 8 Gaullier...
متن کاملInsulin Stimulates Translocation of Human GLUT4 to the Membrane in Fat Bodies of Transgenic Drosophila melanogaster
The fruit fly Drosophila melanogaster is an excellent model system for studies of genes controlling development and disease. However, its applicability to physiological systems is less clear because of metabolic differences between insects and mammals. Insulin signaling has been studied in mammals because of relevance to diabetes and other diseases but there are many parallels between mammalian...
متن کاملAlternative routes to the cell surface underpin insulin-regulated membrane trafficking of GLUT4
Insulin-stimulated delivery of glucose transporters (GLUT4, also known as SLC2A4) from specialized intracellular GLUT4 storage vesicles (GSVs) to the surface of fat and muscle cells is central to whole-body glucose regulation. This translocation and subsequent internalization of GLUT4 back into intracellular stores transits through numerous small membrane-bound compartments (internal GLUT4-cont...
متن کاملDehydroepiandrosterone stimulates glucose uptake in human and murine adipocytes by inducing GLUT1 and GLUT4 translocation to the plasma membrane.
Dehydroepiandrosterone (DHEA) has been shown to modulate glucose utilization in humans and animals, but the mechanisms of DHEA action have not been clarified. We show that DHEA induces a dose- and time-dependent increase in glucose transport rates in both 3T3-L1 and human adipocytes with maximal effects at 2 h. Exposure of adipocytes to DHEA does not result in changes of total GLUT4 and GLUT1 p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2019
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jc.2018-02778